Epidemiology of Pancreatitis and Major Gastrointestinal Diseases- A multi-centre study across India- An ICMR Task Force Project

stomach Infection

Funding agency: Indian Council of Medical Research (ICMR)

Project start date: 15-03-2022

Objectives of the study:

Component 1: Epidemiology of Pancreatitis 

1a: Chronic pancreatitis

  1. To estimate the burden (epidemiological, economic, and disability) due to chronic pancreatitis in different regions of India through a population-based survey
  2. To identify environmental and genetic risk factors for chronic pancreatitis in India

1b: Acute pancreatitis

3. To estimate the annual incidence of acute pancreatitis in India through hospital-based surveillance

Component 2: Prevalence of major gastrointestinal diseases

  1. To estimate the population-level prevalence of major recurrent or chronic gastrointestinal diseases at the national level in population above 18 years of age
  2. To compare the differences in the pattern of major gastrointestinal diseases in different regions of India.

Work done:

  • Training of study sites at THSTI, Faridabad.
  • Piloting of population-based survey for screening of chronic pancreatitis (CP) and GI diseases.
  • Selection of 20 urban and 20 rural CEBs for main study through simple random sampling.
  • Initiation of field survey for screening of CP and GI diseases in urban CEBs.
  • Mapping and listing of CEBs.
  • Completion of field survey for screening of CP and GI diseases in urban CEBs.
  • Initiation of field survey for screening of CP and GI diseases in rural CEBs.
  • Mapping and listing of CEBs.
  • Conduction of Validation activity for Screening Criteria of CP in Gastroenterology department, AIIMS Jodhpur.
  • Initiation of hospital-based study for Acute Pancreatitis (AP).
  • First contact with private and government hospitals for inclusion in AP study.
  • Preparation of annual report of the project for Annual Investigator’s Meeting at ICMR HQs, New Delhi.
  • Preparation of ‘Statement of Expenditure’ and ‘Utilization Certificate’ for Annual Budget Report.


  • Population-based field survey for CP and GI diseases in rural CEBs.
  • Data entry in the ODK app.
  • Query resolution in ODK portal.
  • Follow-up with hospitals regarding consent for AP study.
  • Data collection for AP study from AIIMS Jodhpur- Department of Gastroenterology and Department of Gastro-surgery.


Project Name- National Clinical Registry of COVID-19 India


Funded by: ICMR Delhi, started in August,2020


The overall aim of the proposed clinical registry is to develop a national COVID-19 registry that collects good quality, real-time data for evidence-based decision-making in clinical practice, public health program, and policy.


Primary objective:

  1. To develop a digital COVID-19 registry to collect data regarding clinical and laboratory features, treatments, and outcomes of hospitalized COVID-19 patients in India.
  2. To study the frequency, clinical and laboratory features, treatments, and outcomes of COVID-19-related multisystem inflammatory disorder in children and adolescents by analyzing the national COVID-19 registry.

Secondary objectives- 

  1. The data could be used to answer research questions on COVID-19 including
    • Natural Course of the Disease
    • Disease Spectrum
    • Prognostic Factors
    • Risk Factors
    • Outcomes Data - Medications, health systems.
    • Context-specific questions - Like COVID in Tuberculosis, Malnutrition etc.
  2. To serve as a platform for additional clinical research studies in selected sites.
  3. To collect follow-up data of COVID-19 patients discharged from Registry Sites.
  4. To undertake verbal autopsy (VA) of death among patients diagnosed withCOVID-19 and were discharged after being clinically stable.
  5. To enable early detection of the increase in the proportion of COVID-19-positive cases among total hospitalized at the sentinel surveillance sites/registry sites
  6. To quantify COVID-19 severity in terms of oxygen supplementation, ventilator use, ICU utilization, and mortality. 

Work done under NCRC:

  • Enrolled all COVID-19-positive patients admitted to the study site (AIIMS hospital)
  • Follow-ups of discharged or lama patients 1 month/3 month/6 month/1 year.
  • Conducted Verbal autopsy through video calls and updated ICMR
  • Entered COVID-19 vaccination details of patients admitted to hospital or study site.
  • Entered the total number of patients on the ICMR portal who were admitted to the study site.


  • Follow-ups of the discharged/ lama patients.
  • Entry of the total number of patients and COVID-19-positive patients on the ICMR portal who were admitted to the study site on a daily basis.
  • Preparing the UC/SOE.


  • Effect of COVID-19 vaccine on thrombotic events among 18–45-year-old population in India, 2022: Multicentric hospital-based matched Case-control study (CVT). In the CVT study, we collected all cases and controls from the different departments and prepared a line list of patients. After that who was eligible for the study, we called them and took verbal consent on telephonic interviews.
  • Factors associated with sudden deaths among adults aged 18–45 years, India: Multicentric matched case-control study (SADS): In the SADS study, we collected all cases from the emergency department to determine the factors associated with sudden deaths among previously apparently healthy individuals aged 18-45 years. And called those patients to convince them to visit their houses and do the verbal autopsy.